مرکز آموزشی، پژوهشی و درمانی دکتر شيخ

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Abstracts for the 9th Congress of the Asian Pacific Society of Respirology
10–13 December 2004, Hong Kong

Editors:
Dr K.S. Chan - Dr P.C. Wong

A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF HOUSE DUST MITE IMMUNOTHERAPY IN ASTHMATIC PATIENTS IN CHINA HONGYU WANG1, XIAOPING LIN2, CHUANGLI HAO3, CHUNQING ZHANG1, BAOQING SUN1, JINGPING ZHENG1, PING CHEN2, JINYUN SHENG3, ADRIAN WU4, NANSHAN ZHONG1
1Guangzhou Institute of Respiratory Diseases, 2Shenyang General Military Hospital, 3Suzhou Children’s Hospital, 4Department of Medicine, The University of Hong Kong Background The purpose of this study was to determine if house dust mite immunotherapy is effective in improving symptom control and reducing rescue medication use in Chinese patients with mild to moderate allergic asthma. Methods This is a double-blind, placebo-controlled study involving 132 asthmatic subjects aged 6 to 45 years recruited from 3 different regions of Mainland China. Subjects were given a 52-week course of Alutard Der P (ALK-Abello, Horsholm, Denmark) treatment or placebo while the dose of inhaled corticosteroids (ICS) was maintained.

Results 129 subjects (64 active) completed the study. The symptom scores began to diverge at week 25 with the immunotherapy group showing a significantly lower score until week 48 (P = 0.018). Immunotherapy resulted in a significant decline in symptom (P = 0.003) and medication (P = 0.044) scores during the second half of the treatment period only in subjects who were taking ICS. Subjects on ICS also showed significant improvement in PEF after immunotherapy, but no difference in histamine PC20 was found. Serum ECP and blood eosinophils decreased after immunotherapy in subjects not using ICS. Skin test response decreased in immunotherapy subjects only, and Der P-specific IgE decreased in placebo but not immunotherapy subjects. Immunotherapy resulted in a significantly greater improvement in self-evaluation scores (P < 0.01). Conclusions One year of immunotherapy with Alutard Der P significantly reduced symptoms and medication use in asthmatic subjects, particularly in
those who were already using ICS. This was associated with a greater subjective improvement in asthma control.

ASSOCIATION OF TOTAL PLASMA IGE LEVELS AND ASTHMA IN ASIAN POPULATIONS WD ZHANG, XZ ZHANG, DW QIU, WC TAN
Department of Medicine, National University of Singapore Background Previous studies demonstrated that high levels of serum IgE was associated with asthma and other allergic diseases. Objectives To determine and compare the total plasma IgE levels in both asthmatics and healthy controls in Chinese, Malay and Indian in Singapore. Methods Both 311 asthmatics (Chinese 150; Malay 74; Indian 87) and 355 healthy subjects (Chinese 156; Malay 98; Indian 101) were being participated in a genetic study of asthma. Total plasma IgE levels were determined by Enzyme-linked immunosorbent assay (ELISA). A binary
logistic model was used to detect the association between total plasma IgE levels and asthma.

Results Plasma total IgE was significantly higher in patients group than that of control group in each ethnicity (Chinese: P = 0.049; Malay: P = 0.002; Indian: P = 0.000). Plasma total IgE (Geometric mean) in Chinese (382 IU/ml) was significantly lower than that in Malay (584 IU/ml) and Indian (990 IU/ml) in the patient group (P = 0.000). However, there was no difference for plasma total IgE among Chinese (256 IU/ml), Malay (226 IU/ml) and Indian (323 IU/ml) (P = 0.385) in the control group. Conclusion High level of plasma total IgE may be a risk factor for asthma in Chinese, Malay and Indian. Total plasma IgE levels showed homogeneous among the three ethnicities.

 

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OFIS Theses Supervision - Ghazvin University of Medical Sciences - Assist. prof. general surgery sadegh sadeghipour Roudsari

Accuracy of preoprative diagnosis of acute appendicitis in shahid Rajaie hospital

1995 -

Dr. Sadegh SADEGHIPOUR R.

Research thesis. my position: Supervisor.

level: Doctoral.

place: haspital rajaei

Background :Accuracy of preoperative diagnosis should be about 85%.Less than 85% Indicates unnecessary operation and more than 90%presents the fact that some patients with acute appendicitis are being observed,while,they should have prompt surgical interventions.

Objective: To determine the accuracyof preoperative diagnosis of acute appendicitis.

Methods: surgical and pathological notes of all patients (601cases)who where operated for acute appendicitis in 1995 at Shahid Rajaie hospital were reviewed.

Finding: Only 521 patients had acute appendicitis and no pathological finding were found for the rest.The accuracy of the preoperative diagnosis of acute appendicitis at Shahid Rajaie hospital center was 86.6%.

Conclusion: The accuracy of acute appendicitis diagnosis in patient who undergo appendectomy was acceptable.

Keywords: Acute appendicitis,Accuracy of diagnosis.

 

a STUDY OF HYDROSTATIC REDUCTION IN INTUSSUSCPTION BY ULTRASONIC GUID IN DR. SHAIKH HOSPITAL

January 20, 2005 - 2005

SAID ALI ALAMDARAN SADEGH SADEGHIPOUR ROODSARI

Research thesis. my position: Supervisor.

level: Specialist.

place: DR. SHAIKH CHILDRE HOSPITAL,MASHAD UNIVERSITY OF MEDICAL SIENCES

Survey of road injuries in Qazvin

1997 - 1998

Sadeghipour Sadegh

Research thesis. my position: Supervisor.

level: Doctoral.

place: Shahid Rejaei haspital

Background: Trauma is one of the most common causes for emergency room referral & also the main cause for death in the first four decades of life. Objective: To determine the incidence of different types of road injuries at Qazvin hospitals. Methods: Using questionnaires, all the road accident casualties hospitalized at Shahid Rajaee’s (From June 1997 till July 1998) were incessantly visited through a descriptive study. Findings: 11.3% of emergency room referral was due to car accidents about half of which were road accidents. 53% of referrals were hospitalized most of which substained injury on Tehran-Qazvin highway. Injuries in order of frequency were as follows: Head trauma (49%), soft tissue injury (48%), Fractures (47%), abdominal injury (12%) and chest trauma (13%). Mortality of hospitalized casualties was (11%) & overall mortality of road accident casualties was more than 23% most of which were due to head injury. Conclusion: Increase in morbidity & mortality may be indication of traffic unsafely on Qazvin roads.

A Study of clinical symptom and pathological variant in patient with gastric cancer, in shahid Rajaei hospital Qazvin

1996 - 1997

DR Sadegh sadeghipour

my position: Supervisor.

level: Doctoral.

place: Qazvin University of Medical Sciences

In the study of 87 casses gastric carcinoma which of operated in shahid Rajaei hospital during the 1993 -1995 .The following result were obtained, the stady was performed retrospectivelly.

Nomber of patient were 87, with65 male and 22 famale(M/F 3/1).

Most of patients were in the age group of 60-69 years.

Most of patients have low socioeconomic status.

The common clinical sign were: Abdominal pain (81.6%), weight loss(77%)and Anurexia(52.9%).

The most common group was A (47%). The most common site of stomach was in antrum & pylorus (41.9%).

The most common pathology was adenocarcinoma (96.8%) and most of them were poory differentiated (36.7%).

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MONDAY, SEPTEMBER 19TH 2005

218. Advances in pulmonary radiology

P2061
Influence of clinical characteristics of pulmonary embolism (PE) patients on helical CT performance Luis Hernández1, Sergio Alonso2, Alejandro Muñoz1, Juan Arenas2, Santos Asensio1, Santiago Romero1 . 1Respiratory, Hospital General
Universitario, Alicante, Alicante, Spain; 2Radiology, Hospital General Universitario, Alicante, Alicante, Spain
Aims: To determine if the clinical characteristics of patients with acute PE,
stratified according to Stein’s syndromes (Chest 1997; 112: 974), influence the
diagnostic accuracy of helical CT. Methods: 275 patients (79% outpatients) with clinically suspected PE (mean age 66±15 years and 54% males) were included and prospectively followed up to 3 months. The localization of the PE was registered as the proximal limit of the emboli detected: Central PE (within main to lobar pulmonary arteries), and Peripheral PE (filling defects within segmental and subsegmental arteries).

Results: Helical CT correctly identified 79 of 95 patients with PE (83%). Among these 95 PE patients, 54% presented with the syndrome of pulmonary hemorrage or infarction; 26% with the syndrome of isolated dyspnea and 15% with circulatory collapse. Six patients were not symptomatic.

 

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CONGENITAL POUCH COLON WITH IMPERFORATE ANUS; A REPORT OF 3 CASES

SADEGHIPOUR ROODSARY S.*,HIRADFAR M.,ZABOLINEJAT N.,ALAMDARAN S.A

Congenital pouch colon (CPC) is an unusual condition in imperforate anus (IA), usually of high variety. This malformation is mostly reported from India, where it comprises about 7% of all anorectal malformations. In this anomaly, the normal colon is very short or absent and is replaced by a pouch like dilatation that usually communicates through a fistula with genitourinary tract or persistent cloaca. We are reporting on three cases of newborns (2 females, and 1 male) with this anomaly diagnosed during September 2001 to September 2004. These three cases comprise less than 3% of all cases of IA during this time period. The two girls had anorectal agenesia, short segment of colon and a pouch with vaginal fistula and persistent cloaca (Type II). Colon in the third case was replaced by a dilated pouch that communicated with a wide fistula to the bladder (Type I). This is very important for pediatric surgeons to be aware of the features of this condition to allow for proper diagnosis and surgical management.

Keyword:Pouch Colon, Imperforate Anus, Anorectal Malformation

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Trials. 2006 Jan 18;7:2.

Links

Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus:
design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784].

Eftekhar B, Ghodsi M, Hadadi A, Taghipoor M, Sigarchi SZ, Rahimi-Movaghar V, Kazemzadeh ES, Esmaeeli B, Nejat F, Yalda A, Ketabchi E.

Sina Trauma and Surgery Research Center and Department of Neurosurgery, Sina Hospital, Tehran University, Iran. eftekhar[at]sina.tums.ac.ir

BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients. METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma. CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.

PMID: 16542035 [PubMed]

1: J Neurosurg. 2006 Mar;104(3 Suppl):210-1.

Links

Posterior spinal cord herniation into an extradural thoracic arachnoid cyst: surgical treatment. Case report and review of the literature.

Nejat F, Cigarchi SZ, Kazmi SS.

Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran. nejat[at]sina.tums.ac.ir

The authors describe the case of a 2-year-old boy who experienced progressive spastic paraparesis for several months. Magnetic resonance imaging revealed an extensive extradural arachnoid cyst at the T3-L1 levels and posterior spinal cord herniation at T3-4. Surgical release of the neck of the hernia and total resection of the arachnoid cyst were performed. The patient had good clinical recovery several weeks after surgical decompression. This case highlights an exceedingly rare type of spinal cord herniation in a pediatric age group, and focuses on the abnormalities of the dorsal dura mater, together with imaging and intraoperative findings.

PMID: 16572642 [PubMed - indexed for MEDLINE]