Predictive Factors of Pediatric Intractable Seizures

Javad Akhondian MD^•* , Farhad Heydarian MD** , Seyed-Ali Jafari MD**

Background: This study was performed children aged <15 years, at the Pediatric Neurology Clinic of lmam Reza Hospital affiliated to Mashhad University of Medical. The objective of this study was to recognize the main predisposing factors that result in uncontrolled seizures in patients so that we can start the treatment accurately.

Methods: There were two groups of patients; group l, consisted 51 patients, with minimum refractory seizures of one episode per month while taking at least two antiepileptic drugs, and group ll. Comprised of 80 well- controlled patients chosen at random, who had no fit within 6 months after starting the treatment.

Results: Factors affecting the occurrence of refractory seizures included age<1 years, multiple seizures before starting the treatment, male gender, myocolonic seizures, neurologic defects, neonatal and daily sezures, and first abnormal electroencephalogram and brain computerized tomography scan.

Conclusion: There are several factors that can predict development of uncontrolled seizures Knowledge of these factors helps us to discriminate our patients and pay more attention to those at risk of developing uncontrolled seizures.

Keywords: Elecroencephalogram (EEG).intractable seizures. Status epilepticus