Pattern of factor VIII inhibitors in patients with hemophilia A in the north east of Iran

Authors: Modaresi, A. R.1; Mansouri Torghabeh, H.2; Pourfathollah, A. A.2; Mahmoodian Shooshtari, M.3; Rezaie Yazdi, Z.4

Source: Hematology, Volume 11, Number 3, June 2006, pp. 215-217(3)

Publisher: Taylor and Francis Ltd previous article

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Abstract:

This survey was conducted to evaluate coagulation factor VIII:C inhibitors among 102 hemophilia A patients from different cities of Khorasan province in north east of Iran in order to identify and characterize the pattern of inhibitor formation in these patients population. For this purpose, we randomly obtained plasma samples of 102 hemophilia A patients (44 patients with severe, 28 patients with intermediate and 30 patients with mild hemophilia A) and studied them using two tests: the APTT mix and Bethesda test were performed. In the whole group 20 patients (19.6%) factor VIII inhibitors were detected. These were in 11 patients with severe, five patients with intermediate and four patients with mild hemophilia A. None of patients with hemophilia A had previously been studied for the presence of an inhibitor, so there was no existing history of inhibitor evaluation.

Keywords: Hemophilia A; factor VIII inhibitor; Khorasan province; Iran

Document Type: Research article

DOI: 10.1080/10245330600667526

Affiliations: 1: Pediatric Hematology Group, Dr Sheikh Hospital, Mashad, Iran 2: Hematology Group, Medical Science School, Tarbiat Modarres University, Tehran, Iran 3: Blood Transfusion Organization, Tehran, Iran 4: Internal ward of Ghaem Hospital, Masshad, Iran