Pattern of factor VIII inhibitors in patients with hemohilia A in the north east of Iran

Authors: A.R.Modaresi^a ,H.Mansori Toghabeh^b , A.A. Pourfathollah^b; H. Mahmoodian Shooshtari^c ; Z.Rezaei Yazdi ^d

Affiliations: paediatric Hematology Group,Dr sheikh Hospital.Mashad.Iran ^bHematology Group, Medical Science School, Tarbiat Modarress

University.Tehran.Iran

^C Boold Transfusion Organization. Tehran. Iran

^D Internal ward of Ghaem Hospital.Masshad. Iran

Abstract

This survey was conducted to evaluate coagulation factors VIII:C inhibitors among 102 hemophilia A patients from different cities of Khorasan province in north east of in order to identify and characterize the pattern of inhibitor formation in these patients population . For this purpose, we randomly obtained plasma samples of 102 hemophilia A patients (44 patients with severe , 28 patients with intermediate and 30 patients with mild hemophilia A) and studied them using two tests: the APTT mix and Bethesda test were performed. In the whole group 20 patients (19.6%) factor VIII inhibitors were detected. These were in 11 patients with severe , five patients with hemermediate and four patients with mild hemophilia A. None of patients with hemophilia A had previously been studied for the presence of an inhibitor , so there was no existing history of inhibitor evaluation.

Keywords: Hemophilia A. factor VIII inhibitor; Khorasan province; Iran